About Wockhardt Promethazine with Codeine
About Wockhardt Promethazine with Codeine
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To help protect against withdrawal, your physician may perhaps reduce your dose slowly but surely. Withdrawal is much more likely Should you have employed this medication for a long time (quite a lot of months) or in superior doses. Explain to your physician or pharmacist right away In case you have withdrawal.
See comprehensive prescribing facts for comprehensive boxed warning. Promethazine with Codeine Oral Solution exposes consumers to dangers of addiction, abuse, and misuse, which can lead to overdose and Loss of life. Evaluate affected individual’s possibility before prescribing and monitor closely for these behaviors and disorders. ( 5.one) Serious, lifetime-threatening, or fatal respiratory despair may possibly occur. Watch intently, Specially on initiation or when used in people at higher threat. ( 5.two) Accidental ingestion of Promethazine with Codeine Oral Solution, Primarily by little ones, may result in a deadly overdose of codeine. ( five.2) Lifetime-threatening respiratory despair and Demise have transpired in young children who acquired codeine; most cases followed tonsillectomy and/or adenoidectomy, and several of the kids had evidence of becoming an extremely-speedy metabolizer of codeine as a result of a CYP2D6 polymorphism. ( 5.three) Promethazine with Codeine Oral Solution is contraindicated in children more youthful than 12 a long time of age and in little ones young than 18 many years of age next tonsillectomy and/or adenoidectomy. ( 4) Avoid the usage of Promethazine with Codeine Oral Solution in adolescents 12 to 18 years of age who have other chance things which will boost their sensitivity to your respiratory depressant outcomes of codeine. Postmarketing situations of respiratory depression, together with fatalities are claimed with use of promethazine in pediatric individuals. Children may be especially sensitive on the additive respiratory depressant effects when promethazine is combined with other respiratory depressants, which includes codeine.
Bluish lips or pores and skin chills clay-coloured stools cold sweats confusion cough darkish urine minimize during the frequency of urination decrease during the urine volume diarrhea tricky or troubled breathing problem in passing urine (dribbling) dizziness dizziness, faintness, or lightheadedness when receiving up from lying or sitting posture fast, pounding, or irregular heartbeat or pulse feeling of warmth fever headache superior fever hives or welts, itching, or rash improved perspiring irregular, rapid or gradual, or shallow respiration large, hive-like swelling around the facial area, eyelids, lips, tongue, throat, arms, legs, feet, or intercourse organs lack of appetite lack of bladder Handle nausea noisy respiration not breathing agonizing urination pale or blue lips, fingernails, or skin rectal bleeding redness of your face, neck, arms, and occasionally, upper chest redness of the pores and skin looking at, Listening to, or sensation points that aren't there seizures significant muscle mass stiffness shakiness within the legs, arms, or fingers belly soreness sweating tightness from the upper body tiredness trembling or shaking from the fingers or feet disagreeable breath odor unusual tiredness or weak spot unusually pale pores and skin vomiting of blood yellow eyes or pores and skin Get unexpected emergency assistance immediately if any of the next signs or symptoms of overdose arise:
On account of similar pharmacologic Homes, it is actually affordable to be expecting similar threat with concomitant utilization of opioid cough prescription drugs and benzodiazepines, other CNS depressants, or alcohol.
Neuroleptic malignant syndrome (NMS) which can lead to death. Let you know Health care provider straight away When you've got any of the next signs or symptoms of NMS:
Results around the Immune Technique Opioids are revealed to get several different consequences on elements on the read more immune process in in vitro and animal versions. The medical importance of those results is unknown. In general, the results of opioids appear to be modestly immunosuppressive.
At least 1 death was documented in the nursing toddler who was subjected to large levels of morphine in breast milk because the mother was an ultra-rapid metabolizer of codeine.
We foresee reposting the images at the time we've been capable identify and filter out pictures that don't match the information supplied while in the drug labels. NDC Codes
This medication might make you much more delicate to your Sunlight. Restrict your time and energy during the sun. Stay away from tanning booths and sunlamps. Use sunscreen and use protecting outfits when outside. Notify your medical professional right away if you receive sunburned or have skin blisters/redness.
Life-threatening respiration difficulties (respiratory depression). Promethazine Hydrochloride and Codeine Phosphate Oral Solution can result in respiration difficulties (respiratory melancholy) that may materialize at any time in the course of remedy and can cause Loss of life. Your threat of respiratory troubles is finest when you to start with start getting Promethazine Hydrochloride and Codeine Phosphate Oral Solution, are taking other medicines that could cause respiration difficulties, have specific lung challenges, are elderly or have selected other health conditions.
Pregnancy Tests: Diagnostic pregnancy checks depending on immunological reactions among HCG and anti-HCG may perhaps bring about Untrue-damaging or Fake-constructive interpretations.
The precise mechanism of motion of codeine as well as other opiates just isn't acknowledged; nonetheless, codeine is thought to act centrally around the cough center. In too much doses, codeine will depress respiration.
Notify your healthcare service provider about all of the medicines you take, together with prescription and about-the-counter medicines, nutritional vitamins, and herbal dietary supplements. Taking PROMETHAZINE WITH CODEINE ORAL SOLUTION with specific other medicines might cause Negative effects or have an effect on how nicely PROMETHAZINE WITH CODEINE ORAL SOLUTION or the other medicines work. Will not get started or stop taking other medicines without conversing with your Health care company.
The respiratory depression will involve a reduction in the responsiveness on the brain stem respiratory facilities to both of those boosts in carbon dioxide tension and also to electrical stimulation.